Difference between revisions of "Part:BBa K3117004"
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<partinfo>BBa_K3117004 short</partinfo> | <partinfo>BBa_K3117004 short</partinfo> | ||
| − | [[File:G4S_4_Linker.gif | + | [[File:G4S_4_Linker.gif|right|alt text]] |
The linker BBa_K3117004 consists of four repeats of four times glycin and one time serin. (Gly4Ser)4 linker is one of the most widely used flexible linker that can sustain the bioactivity of fusion proteins. It was used by the team FAU_Erlangen, 2019, to create a bispecific antibody targeting GPA33 on colorectal cancer cells and CD3 on T cells (<partinfo>BBa_K3117029</partinfo>, <partinfo>BBa_K3117026</partinfo>, <partinfo>BBa_K3117030</partinfo>). | The linker BBa_K3117004 consists of four repeats of four times glycin and one time serin. (Gly4Ser)4 linker is one of the most widely used flexible linker that can sustain the bioactivity of fusion proteins. It was used by the team FAU_Erlangen, 2019, to create a bispecific antibody targeting GPA33 on colorectal cancer cells and CD3 on T cells (<partinfo>BBa_K3117029</partinfo>, <partinfo>BBa_K3117026</partinfo>, <partinfo>BBa_K3117030</partinfo>). | ||
Revision as of 20:28, 21 October 2019
((Glycine)x4-Serine)x4 Linker
The linker BBa_K3117004 consists of four repeats of four times glycin and one time serin. (Gly4Ser)4 linker is one of the most widely used flexible linker that can sustain the bioactivity of fusion proteins. It was used by the team FAU_Erlangen, 2019, to create a bispecific antibody targeting GPA33 on colorectal cancer cells and CD3 on T cells (BBa_K3117029, BBa_K3117026, BBa_K3117030).
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]