Difference between revisions of "Part:BBa K3284001:Design"
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===Design Notes=== | ===Design Notes=== | ||
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− | + | In this project, CEAKEER is a synthetically combined receptor used as the diagnostic tool system. TGFBR1, which is originally found in human body, directly interacts with Carcinoembryonic Antigen (CEA). CEA itself functions as an intercellular adhesion molecule and is upregulated in a wide variety of human cancers, including lung cancer. CEA-binding domain mainly lodged in TGFBR1’s extracellular environment. Hence, the domain, boarden between 1th-126th amino acid, was chosen from TGFBR1. Furthermore, Transcriptional Coactivator with PDZ-binding motif (TAZ) consists of Tar receptor, Tar HAMP domain, and EnvZ histidine kinase domain. It presents as an oncogene that is used for the early detection of lung cancer. Therefore, our team selected Taz domains involving 1st-40th and 167th-484th amino acid as part of CEAKEER | |
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===Source=== | ===Source=== |
Revision as of 17:57, 21 October 2019
TGFbRI/Taz Chimeric Receptor Device
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Design Notes
- In this project, CEAKEER is a synthetically combined receptor used as the diagnostic tool system. TGFBR1, which is originally found in human body, directly interacts with Carcinoembryonic Antigen (CEA). CEA itself functions as an intercellular adhesion molecule and is upregulated in a wide variety of human cancers, including lung cancer. CEA-binding domain mainly lodged in TGFBR1’s extracellular environment. Hence, the domain, boarden between 1th-126th amino acid, was chosen from TGFBR1. Furthermore, Transcriptional Coactivator with PDZ-binding motif (TAZ) consists of Tar receptor, Tar HAMP domain, and EnvZ histidine kinase domain. It presents as an oncogene that is used for the early detection of lung cancer. Therefore, our team selected Taz domains involving 1st-40th and 167th-484th amino acid as part of CEAKEER
Source
Taz from BBa_C0082