Difference between revisions of "Part:BBa K2976006"

Revision as of 17:05, 21 October 2019

Anti-PD-L1 peptide

Usage and Biology

Anti-PD-L1 peptide selectively binds to programmed death ligand 1 (PD-L1), an immune checkpoint protein that is overexpressed in many cancer cell lines. Recent study has demonstrated that the Mtb-infected macrophages express more PD-L1 than normal ones. Thus, PD-L1 could be a promising target for intracellular Mtb therapy. In 2019 CPU_CHINA project, anti-PD-L1 peptide is displayed on the surface of the exosome to specifically targeting the Mtb-infected macrophages.

Characteristics

Anti-PD-L1 peptide was designed as a fusion protein with lamp2 and HA tag. With the detection of HA tag(Fig.1), the expression of anti-PD-L1 was confirmed as well.

Figure 1: Western blot result of exosome protein.

Sequence and Features