Difference between revisions of "Part:BBa K3234000"

Revision as of 23:56, 20 October 2019

Human interleukin 2

Interleukin-2 (IL-2) is a pleiotropic cytokine, and involves in immune regulation by controlling the differentiation and homeostasis of both pro- and anti-inflammatory T cells. As a naturally occurring cytokine made by T-lymphocytes, IL-2 stimulates the growth and activity of other T-lymphocytes and B-lymphocytes as part of the immune system. Many investigators explored IL-2 and/or IL-2-activated effectors for a variety of malignancies with encouraging but inconclusive results3. IL-2 has been approved by the U.S. Food and Drug Administration (FDA) to treat patients with stage IV (metastatic) melanoma since 1998. The sequence is codon optimized for expression in E coli.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 181

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 <partinfo>BBa_K3234000 short</partinfo>
-nterleukin-2 (IL-2) is a pleiotropic cytokine, and involves in immune regulation by controlling the differentiation and homeostasis of both pro- and anti-inflammatory T cells. As a naturally occurring cytokine made by T-lymphocytes, IL-2 stimulates the growth and activity of other T-lymphocytes and B-lymphocytes as part of the immune system. Many investigators explored IL-2 and/or IL-2-activated effectors for a variety of malignancies with encouraging but inconclusive results3. IL-2 has been approved by the U.S. Food and Drug Administration (FDA) to treat patients with stage IV (metastatic) melanoma since 1998.
+Interleukin-2 (IL-2) is a pleiotropic cytokine, and involves in immune regulation by controlling the differentiation and homeostasis of both pro- and anti-inflammatory T cells. As a naturally occurring cytokine made by T-lymphocytes, IL-2 stimulates the growth and activity of other T-lymphocytes and B-lymphocytes as part of the immune system. Many investigators explored IL-2 and/or IL-2-activated effectors for a variety of malignancies with encouraging but inconclusive results3. IL-2 has been approved by the U.S. Food and Drug Administration (FDA) to treat patients with stage IV (metastatic) melanoma since 1998.
 The sequence is codon optimized for expression in E coli.