Difference between revisions of "Part:BBa K3064009"

Revision as of 09:06, 20 October 2019

mmuIgG-Fc

Immunoglobulin G (IgG) is a type of antibody, containing the fragment crystallizable region(Fc).

Usage and Biology

As a type of antibody, IgG binds many kinds of pathogens and protects the body from infection. IgG shapes like a Y due to its tetrameric quaternary structure, with two identical class heavy chains and two identical light chains. On the bottom of the heavy chain is the Fc domain. Fc mediates different physiological effects of antibodies by interacting with various cell receptors and complement proteins. Also, it can be recognized and bound with TRIM21,an E3 ubiquitin-protein ligase that has been applied to a protein degradation method known as Trim-Away.

In our project, this part is linked with glucagon. Glucagon binds to glucagon receptor(GCGR), Fc domain recruits the TRIM21, leading to the ubiquitination and final degradation of GCGR.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal BsaI.rc site found at 7

References

1.IgG http://wikipedia.moesalih.com/IgG

2.Fc http://wikipedia.moesalih.com/Fragment_crystallizable_region

@@ Line 10: / Line 10: @@
 In our project, this part is linked with glucagon. Glucagon binds to glucagon receptor(GCGR), Fc domain recruits the TRIM21, leading to the ubiquitination and final degradation of GCGR.
@@ Line 16: / Line 17: @@
 <partinfo>BBa_K3064009 SequenceAndFeatures</partinfo>
+===References===
+.IgG http://wikipedia.moesalih.com/IgG
+.Fc http://wikipedia.moesalih.com/Fragment_crystallizable_region
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