Difference between revisions of "Part:BBa K141000"

Revision as of 13:37, 8 October 2008

Ucp1

The uncoupling protein UCP+ is a proton carrier characteristic of brown adipose tissue. UCP+ uncouples the respiratory chain of ATP production, converting the metabolic energy in heat. UCP+ is a 33kd protein which is exclusively located in the brown adipocites. It is an integral protein present in inner mitocondrial membrane. The protein has a tripartite structure. The structure displays an around 100 residues region which is three times repeated. Each part encodes for two transmembrane segments and one long hydrophilic loop.The functional carrier unit is an homodimer. The main difference between UCP+ and most of the proteins with a nuclear codification is the lack of the importation targeting to the mitochondria in UCP+ proteins. The condition that determines the mitochondria as the protein target lays in the first loop which protudes in the mitochondrial matrix. The second loop of the matrix is essential for the insertion of the protein in the inner mitochondrial matrix. Purine nucleotides act as inhibitors of protein activity and esterificated fatty acids act as inductors.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 47
Illegal BglII site found at 347
Illegal BamHI site found at 835
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal NgoMIV site found at 58
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K141000 short</partinfo>
-The Ucp1 is a DNA part which encodes for a protein called UCP1 which belongs to the uncuopling proteins family.
+The uncoupling protein UCP+ is a proton carrier characteristic of brown adipose tissue.
-The uncoupling proteins (UCPs) are transporters, presents in the mitochondrial inner membrane, that mediate a regulated discharge of the proton gradient that is generated by the respiratory chain.
+UCP+  uncouples the respiratory chain  of ATP production, converting the metabolic energy in heat.
-This energy-dissipatory mechanism can serve functions such as termogenesis.
+[[Image:function.jpg]]
-The protein is regulated by acivation and inhibition in the mitochondrion. The proton conductance in UCP1 is inhibited by nucleotides and activated by fatty acids.
+UCP+ is a 33kd protein which is  exclusively located in the brown adipocites.
+It is an  integral protein present in inner mitocondrial membrane.
+The protein has a tripartite structure. The structure displays an around 100 residues region  which   is three times repeated. Each part encodes for two transmembrane segments and one long hydrophilic loop.The functional carrier unit is an homodimer.
+[[Image:Structure.jpg]]
+The main  difference between UCP+ and  most of the proteins with a nuclear codification is  the    lack of the importation targeting to the mitochondria in UCP+ proteins.
+The condition that determines the mitochondria as the protein target lays in the first loop which protudes in the mitochondrial matrix.
+The second loop of the matrix is essential for the insertion of the protein in the inner mitochondrial matrix.
+Purine nucleotides act as  inhibitors of protein activity and  esterificated fatty acids act as  inductors.