Difference between revisions of "Part:BBa K3064000"
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===Usage and Biology===
 
===Usage and Biology===
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Some glycolytic and lipogenic genes response primarily to glucose, not to insulin. This led to the identification of a consensus sequence that is required for glucose-responsiveness, termed the carbohydrate response element (ChoRE), comprising of two E-boxes (CACGTG) or E-box-like sequences separated by 5 bp [3-5].
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Carbohydrate response element binding protein (ChREBP) is an important transcription that can regulate the expression of key genes involved in various pathways including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region. ChoRE should be widely applicable to studying the influence of glucose consentration to cells .
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Revision as of 02:46, 27 September 2019


CHoRE

It is a binding site of CHREBP.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]