Difference between revisions of "Part:BBa K2588006"
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| − | <p>CbtA is a cytoskeleton toxin | + | <p>CbtA is a cytoskeleton toxin expressed by <i>E. coli</i>. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of <i>E. coli</i> during cell division as well as for building of the F-ring, to divide the cell.</p> |
<h2>Usage and Biology</h2> | <h2>Usage and Biology</h2> | ||
<p>CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.<sup>1</sup> | <p>CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.<sup>1</sup> | ||
Latest revision as of 01:49, 18 October 2018
Cell division inhibitor cbtA
CbtA is a cytoskeleton toxin expressed by E. coli. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of E. coli during cell division as well as for building of the F-ring, to divide the cell.
Usage and Biology
CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.1
References
- Tan, Q., Awano, N. & Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Mol. Microbiol. 79, 109–118 (2011).
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]