Difference between revisions of "User:Scmohr/Antibiotic-res cat page"
(→5. Components of Altered Metabolic Pathways) |
|||
| Line 23: | Line 23: | ||
===4. Altered Target Molecules=== | ===4. Altered Target Molecules=== | ||
| − | ===5. Components of | + | ===5. Components of Alternative Metabolic Pathways=== |
Revision as of 15:01, 23 July 2008
Contents
Antibiotic Resistance Parts
Introduction to Antibiotic Resistance
The established mechanisms of antibiotic resistance include the following:
1. Enzymes that inactivate the antibiotic [famously (a). beta-lactamases that destroy penicillins and related compounds and (b) enzymes that acetylate chloramphenicol].
2. Proteins that keep antibiotics from entering the cell (by blocking the outer-membrane pores), or actively pump them out after they enter.
3. Alteration of the drug binding site (vancomycin resistance comes from a switch in the chemistry of the cell-wall cross-linking peptide). This category also includes mutations in ribosomal RNA.
4. Substitution of an alternative metabolic pathway (as in the case of sulfonamide resistance).