Difference between revisions of "Part:BBa K2653014"

Revision as of 12:14, 17 October 2018

VEGF

The single-chain variable fragments(scFv)of VEGF.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
INCOMPATIBLE WITH RFC[12]
Illegal NotI site found at 771
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 267
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal BsaI site found at 65

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 <partinfo>BBa_K2653014 short</partinfo>
-VEGF was first identified in guinea pigs, hamsters, and mice by Senger et al. in 1983.1 VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).
+The single-chain variable fragments(scFv)of VEGF.
-When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.
 <!-- Add more about the biology of this part here
 ===Usage and Biology===
+VEGF was first identified in guinea pigs, hamsters, and mice by Senger et al. in 1983.1 VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).
+When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.
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