Difference between revisions of "Part:BBa K2817004"

Revision as of 12:35, 16 October 2018

Myrosinase (horseradish)

Myrosinase is present in cruciferous plants such as broccoli, Brussels sprouts and Celery cabbage. It can convert the precursor glucosinolates in cruciferous plants into sulforaphane, a well-known anticancer substance. Sulforaphane is an activator of Nrf2, which induces Nrf2 activation and translocation into the nucleus, binding to the antioxidant response element (ARE) to promote transcriptional activation of the phase II metabolic enzyme gene. As a result, sulforaphane, on the one hand, can eliminate cancer cells by inducing phase II reaction; on the other hand, it can alleviate inflammation by inducing antioxidant enzymes (such as HO-1 and SOD) to resist oxidative stress. The horseradish enzyme derived from horseradish has good catalytic activity at body temperature and in vivo pH.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal AgeI site found at 139
1000
INCOMPATIBLE WITH RFC[1000]
Illegal BsaI site found at 368
Illegal BsaI site found at 1397

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 <partinfo>BBa_K2817004 short</partinfo>
-Myrosinase converts glucosinolates to sulforaphane. Sulforaphane is an organic molecule with well-known anti-cancer activity.
+Myrosinase is present in cruciferous plants such as broccoli, Brussels sprouts and Celery cabbage. It can convert the precursor glucosinolates in cruciferous plants into sulforaphane, a well-known anticancer substance. Sulforaphane is an activator of Nrf2, which induces Nrf2 activation and translocation into the nucleus, binding to the antioxidant response element (ARE) to promote transcriptional activation of the phase II metabolic enzyme gene. As a result, sulforaphane, on the one hand, can eliminate cancer cells by inducing phase II reaction; on the other hand, it can alleviate inflammation by inducing antioxidant enzymes (such as HO-1 and SOD) to resist oxidative stress. The horseradish enzyme derived from horseradish has good catalytic activity at body temperature and in vivo pH.
 <!-- Add more about the biology of this part here