Difference between revisions of "Part:BBa K2796028"

Revision as of 14:09, 15 October 2018

Exosome booster

Exosome booster is meaning of hSDC4-T2A-STEAP3-P2A-NadB.We identified STEAP3 (involved in exosomebiogenesis), syndecan-4 (SDC4; supports budding of endosomal membranes to form multivesicular bodies), and a fragment of L-aspartate oxidase (NadB; possibly boosts cellular metabolism by tuning up the citric acid cycle) as potential synthetic exosome production boosters. Combined expression of these genes significantly increased exosome production.(Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment; Ryosuke Kojima et al. 2008)

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 192
Illegal BglII site found at 1777
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal AgeI site found at 2657
Illegal AgeI site found at 3277
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI site found at 1367

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K2796028 short</partinfo>
-hSDC4-T2A-STEAP3-P2A-NadB.We identified STEAP3 (involved in exosomebiogenesis), syndecan-4 (SDC4; supports budding of endosomal membranes to form multivesicular bodies), and a fragment of L-aspartate oxidase (NadB; possibly boosts cellular
+<b>Exosome booster</b> is meaning of hSDC4-T2A-STEAP3-P2A-NadB.We identified STEAP3 (involved in exosomebiogenesis), syndecan-4 (SDC4; supports budding of endosomal membranes to form multivesicular bodies), and a fragment of L-aspartate oxidase (NadB; possibly boosts cellular
 metabolism by tuning up the citric acid cycle) as potential synthetic exosome production boosters. Combined expression of
-these genes significantly increased exosome production.
+these genes significantly increased exosome production.(Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment; Ryosuke Kojima et al. 2008)
 <!-- Add more about the biology of this part here