Difference between revisions of "Part:BBa K2619000"

Revision as of 17:34, 14 October 2018

STEAP3 metalloreductase/TSAP6/ferrireductase

STEAP3 metalloreductase, also known as TSAP6 encoding a ferrireductase that is involved in promoting apoptosis and exosome biogenesis. TSAP6 is a glycosylated protein presents in the trans-Golgi network, endosomal–vesicular compartment and cytoplasmic membrane (Lespagnol et al., 2008). One possible mechanism is that TSAP6 regulates its downsteam transferrin receptor genes, which is a process related to exosomal secretion. Although its detailed mechanism of promoting exosome secretion is still unknown, (Lespagnol et al., 2008) have proved that exosome production is severely compromised in TSAP6-null cells. Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 201
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 <partinfo>BBa_K2619000 short</partinfo>
-STEAP3 metalloreductase from Homo sapien is involved in exosome biogenesis. But the detailed mechanism is still unknown
+STEAP3 metalloreductase, also known as TSAP6 encoding a ferrireductase that is involved in promoting apoptosis and exosome biogenesis. TSAP6 is a glycosylated protein presents in the trans-Golgi network, endosomal–vesicular compartment and cytoplasmic membrane (Lespagnol et al., 2008). One possible mechanism is that TSAP6 regulates its downsteam transferrin receptor genes, which is a process related to exosomal secretion. Although its detailed mechanism of promoting exosome secretion is still unknown, (Lespagnol et al., 2008) have proved that exosome production is severely compromised in TSAP6-null cells.
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 ===Usage and Biology===