Difference between revisions of "Part:BBa K2729004"
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==Chactarization== | ==Chactarization== | ||
| − | The DENV E protein is a class II fusion protein, essential for attachment, membrane fusion, and assembly. | + | The DENV E protein is a class II fusion protein, essential for attachment, membrane fusion, and assembly.A series of conformational changes occurring in the DENV E protein driven by the endosomal low-pH gives place to the fusion of the viral and endosomal membranes. |
| + | |||
| + | ==Reference== | ||
| + | - [https://www.sciencedirect.com/science/article/pii/S0005273611001970 Nemésio H, Palomares-Jerez F, Villalaín J. The membrane-active regions of the dengue virus proteins C and E. Biochim Biophys Acta. 2011 Oct;1808(10):2390-402.doi: 10.1016/j.bbamem.2011.06.019. Epub 2011 Jul 13. PubMed PMID: 21777566.] | ||
Revision as of 14:42, 14 October 2018
DENV3 E (Envelope Protein | Dengue Virus Serotype III)
Flavivirus Envelope (E) is a structural protein responsible for gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1307
Illegal XhoI site found at 868 - 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 250
Illegal SapI.rc site found at 1078
Chactarization
The DENV E protein is a class II fusion protein, essential for attachment, membrane fusion, and assembly.A series of conformational changes occurring in the DENV E protein driven by the endosomal low-pH gives place to the fusion of the viral and endosomal membranes.