Difference between revisions of "Part:BBa K2543001"
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===References===
 
===References===
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==== CD4 ====
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1. [https://www.uniprot.org/uniprot/P01730 UniProtKB - P01730 (CD4_HUMAN)] <br />
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1. [https://www.ncbi.nlm.nih.gov/pubmed/11606751 PNAS (2001) Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae.]
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2. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524797/ Retrovirology. (2006) Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry] <br />
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2. [https://www.ncbi.nlm.nih.gov/pubmed/17257211 Insect Mol Biol. (2007) Regulated expression of microinjected DNA in adult Aedes aegypti mosquitoes]
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3. [https://www.ncbi.nlm.nih.gov/pubmed/16709847 J Immunol. (2006) Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.] <br />
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3. [https://www.ncbi.nlm.nih.gov/pubmed/18604274 PLoS Pathog. (2008) The Aedes aegypti toll pathway controls dengue virus infection.]
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4. [https://www.ncbi.nlm.nih.gov/pubmed/16622011 J Immunol. (2006) Triggering of T cell activation via CD4 dimers.] <br />
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4. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291090/ Front Cell Infect Microbiol. (2017) Regulation of Antimicrobial Peptides in Aedes aegypti Aag2 Cells]
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5. [https://www.ncbi.nlm.nih.gov/pubmed/24550395 J Biol Chem. (2014) Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization.] <br />
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5. [https://www.ncbi.nlm.nih.gov/pubmed/28533370 PNAS (2017) Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality.]
  
  

Revision as of 09:24, 11 October 2018


GAM1 promoter / pSB1C3

GAM1 is an inducible promoter from mosquitoes and regulated by Toll signaling in the mosquito defense system. The promoter drives the immune responsive antimicrobial peptide (AMP), Gambicin to kill both Gram-positive and Gram-negative bacteria. And it can control Dengue virus infection and malaria parasite through Toll pathway. It works both in mosquitoes (e.g, Anopheles gambiae, Aedes aegypti, Aedes albopictus, etc.) and insect cell lines (e.g, Drosophila S2 cells, Aag2 cells, C6/36 cells, etc.)

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

1. PNAS (2001) Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. 2. Insect Mol Biol. (2007) Regulated expression of microinjected DNA in adult Aedes aegypti mosquitoes 3. PLoS Pathog. (2008) The Aedes aegypti toll pathway controls dengue virus infection. 4. Front Cell Infect Microbiol. (2017) Regulation of Antimicrobial Peptides in Aedes aegypti Aag2 Cells 5. PNAS (2017) Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality.