Difference between revisions of "Part:BBa K2543006"

 
 
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<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
<partinfo>BBa_K2543006 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K2543006 SequenceAndFeatures</partinfo>
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===References===
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1. [https://www.uniprot.org/uniprot/P01730 UniProtKB - P01730 (CD4_HUMAN)] <br />
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2. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524797/ Retrovirology. (2006) Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry] <br />
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3. [https://www.ncbi.nlm.nih.gov/pubmed/16709847 J Immunol. (2006) Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.] <br />
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4. [https://www.ncbi.nlm.nih.gov/pubmed/16622011 J Immunol. (2006) Triggering of T cell activation via CD4 dimers.] <br />
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5. [https://www.ncbi.nlm.nih.gov/pubmed/24550395 J Biol Chem. (2014) Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization.] <br />
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Latest revision as of 17:46, 8 October 2018


hCD4 extracellular domain / pSB1C3

Human CD4 (hCD4) is a cell marker expressed on the subtype of T helper cell. CD4 acts as a coreceptor to help T cell development and cell function. CD4 plays an important role in T cell activation and immune signaling. The extracellular domain of hCD4 (1-396 aa) can form dimer and regulate the function of T cell activation.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 1138
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 1189
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 370

References

1. UniProtKB - P01730 (CD4_HUMAN)
2. Retrovirology. (2006) Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry
3. J Immunol. (2006) Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.
4. J Immunol. (2006) Triggering of T cell activation via CD4 dimers.
5. J Biol Chem. (2014) Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization.