Difference between revisions of "Part:BBa K2524000"
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The presence of hCG is detectable by immunologic means within days of fertilization and forms the foundation of the common pregnancy tests. The hCG Beta-subunit has the epitopes that are detected by pregnancy tests, when hCG is present a pregnancy test will produce a positive result. It can be used in scenarios when detecting the autocatalysis of an enzyme. When hCG is fused to the end of an enzyme that is immobilized in a solution, if autocatalysis took place the hCG will be released into the solution and produce a positive pregnancy test result. | The presence of hCG is detectable by immunologic means within days of fertilization and forms the foundation of the common pregnancy tests. The hCG Beta-subunit has the epitopes that are detected by pregnancy tests, when hCG is present a pregnancy test will produce a positive result. It can be used in scenarios when detecting the autocatalysis of an enzyme. When hCG is fused to the end of an enzyme that is immobilized in a solution, if autocatalysis took place the hCG will be released into the solution and produce a positive pregnancy test result. | ||
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<img src="https://static.igem.org/mediawiki/2017/d/d9/T--Georgia_State--hcgbetasubunit.jpg" alt="HCGstructure" width="250" height="250" style="float:right;"> | <img src="https://static.igem.org/mediawiki/2017/d/d9/T--Georgia_State--hcgbetasubunit.jpg" alt="HCGstructure" width="250" height="250" style="float:right;"> | ||
</div> | </div> | ||
Revision as of 20:53, 1 November 2017
Synthetic Human Chorionic Gonadotropin (HCG) Beta Subunit
This part is an improvement of Part:BBa_K732001.
Human Chorionic Gonadotropin (hCG) is the hormone made by chorionic cells in the fetal part of the placenta where it stimulates the ovaries to synthesize important steroids for the maintenance of pregnancy. It is a member of the beta chain glycoprotein hormone family. The glycoproteins are heterodimers consisting of an alpha subunit and beta subunit. The beta subunit determines bio-specificity. Six genes encode the hCG beta subunit which are inverted on chromosome 19q13.3 and is boarding the luteinizing hormone beta subunit gene.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]