Difference between revisions of "Part:BBa K2309026"
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The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of our antimicrobial peptides. | The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of our antimicrobial peptides. | ||
| + | A histone H1-derived peptide from the Komodo dragon (Varanus komodoensis)were defined as VK25. a synthetic peptide called DRGN-1 were designed based on VK-25. DRGN-1 has anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus rather than VK-25.Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 08:44, 1 November 2017
Komodo dragon-inspired synthetic peptide DRGN-1 for Lactococcus lactis
The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of our antimicrobial peptides.
A histone H1-derived peptide from the Komodo dragon (Varanus komodoensis)were defined as VK25. a synthetic peptide called DRGN-1 were designed based on VK-25. DRGN-1 has anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus rather than VK-25.Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds. Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]