Difference between revisions of "Part:BBa K2520027"
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<partinfo>BBa_K2520027 short</partinfo> | <partinfo>BBa_K2520027 short</partinfo> | ||
| − | + | ===Diabetes type 1=== | |
| + | Diabetes type 1 is a chronic disease of the pancreas that is caused due to T cells attacking the insulin producing beta cells, within the pancreas. Globally, nearly 40 million people suffer from type I diabetes. This disease leads pancreatic dysfunction and insulin dependence. | ||
| + | <u>Proinsulin</u>: | ||
| + | Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans. | ||
| + | Proinsulin formed by three distinct chains: The A chain, B chain, and the area connecting the two chains - C peptide. | ||
| + | [[File:proinsulin.jpeg|500px|thumb|center|]] | ||
| + | |||
| + | ===References=== | ||
| + | (1) Wong, F. Susan, et al. "Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library." Nature medicine 5.9 (1999): 1026-1031. | ||
| + | |||
| + | (2) Narendran, Parth, Stuart I. Mannering, and Leonard C. Harrison. "Proinsulin—a pathogenic autoantigen in type 1 diabetes." Autoimmunity reviews 2.4 (2003): 204-210. | ||
| + | APA | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Latest revision as of 11:04, 31 October 2017
Pro-insulin
Diabetes type 1
Diabetes type 1 is a chronic disease of the pancreas that is caused due to T cells attacking the insulin producing beta cells, within the pancreas. Globally, nearly 40 million people suffer from type I diabetes. This disease leads pancreatic dysfunction and insulin dependence.
Proinsulin: Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans. Proinsulin formed by three distinct chains: The A chain, B chain, and the area connecting the two chains - C peptide.
References
(1) Wong, F. Susan, et al. "Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library." Nature medicine 5.9 (1999): 1026-1031.
(2) Narendran, Parth, Stuart I. Mannering, and Leonard C. Harrison. "Proinsulin—a pathogenic autoantigen in type 1 diabetes." Autoimmunity reviews 2.4 (2003): 204-210. APA Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]