Difference between revisions of "Part:BBa K1590008"
Line 11: Line 11:
 
===Usage and Biology===
 
===Usage and Biology===
  
−
A majorfound in saliva is a free iron sequestering compound known as lactoferrin, a protein involved in the innate immune system. <i>Neisseria meningitidis</i> is a gram-negative bacterium with an iron-binding outer membrane protein called lactoferrin binding protein A (LbpA). <i>N. meningitidis</i> uses this LbpA to extract iron from the host lactoferrin under pathogenic conditions to allow for the bacterium to perform essential cellular metabolism such as energy generation and DNA replication.
+
A major component found in saliva is a free iron sequestering compound known as lactoferrin, a protein involved in the innate immune system. <i>Neisseria meningitidis</i> is a gram-negative bacterium with an iron-binding outer membrane protein called lactoferrin binding protein A (LbpA). <i>N. meningitidis</i> uses this LbpA to extract iron from the host lactoferrin under pathogenic conditions to allow for the bacterium to perform essential cellular metabolism such as energy generation and DNA replication.
  
  

Revision as of 22:49, 18 September 2015

Lactoferrin Binding Protein

Coding sequence for Lactoferrin Binding Protein of Neisseria meningitidis. This protein sequesters iron for the host from Lactoferrin.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 172
  • 1000
    COMPATIBLE WITH RFC[1000]


Usage and Biology

A major component found in saliva is a free iron sequestering compound known as lactoferrin, a protein involved in the innate immune system. Neisseria meningitidis is a gram-negative bacterium with an iron-binding outer membrane protein called lactoferrin binding protein A (LbpA). N. meningitidis uses this LbpA to extract iron from the host lactoferrin under pathogenic conditions to allow for the bacterium to perform essential cellular metabolism such as energy generation and DNA replication.



Functional Parameters