Difference between revisions of "Part:BBa K1699001:Design"

(→‎Source)
(→‎Source)
Line 11: Line 11:
 
===Source===
 
===Source===
 
Human genomic DNA sequence.
 
Human genomic DNA sequence.
 +
Based on:
 +
Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.
 +
Gu J, Kagawa S, Takakura M, Kyo S, Inoue M, Roth JA, Fang B.
 +
Cancer Res. 2000 Oct 1;60(19):5359-64.
 +
http://www.ncbi.nlm.nih.gov/pubmed/11034071
  
 
===References===
 
===References===

Revision as of 09:51, 13 September 2015

Human short TERT promoter


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

Cloned into pSB1C3 using EcoRI and PstI restrictoion sites.

Source

Human genomic DNA sequence. Based on: Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Gu J, Kagawa S, Takakura M, Kyo S, Inoue M, Roth JA, Fang B. Cancer Res. 2000 Oct 1;60(19):5359-64. http://www.ncbi.nlm.nih.gov/pubmed/11034071

References

1. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters http://www.nature.com/gt/journal/v8/n7/pdf/3301421a.pdf