Difference between revisions of "Part:BBa K1391008:Experience"

Revision as of 22:53, 1 November 2014

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.

Applications of BBa_K1391008

Lyn is a Tyrosine-protein kinase responsible for phosphorylating the immunoreceptor tyrosine-based activation motif (ITAM) of a B-Cell Receptor (BCR) Complex upon antigen binding. When the BCR binds it's specific antigen the receptor dimerizes and recruits Lyn which phosphorylates the ITAMs of the CD79A and CD79B proteins in the BCR Complex. This allows the receptor to phosphorylate Syk and initiate a downstream signalling cascade.

B-cell receptors (BCRs) are naturally occurring, transmembrane protein complexes that consist of a membrane-bound antibody (IgM) and some associated proteins (CD79A and CD79B). Given that the variable region of the antibody can be specific for any of a large number of antigens, we designed a B-cell receptor to bind beta-amyloid plaques (a biomolecular hallmark of Alzheimer's disease). Once bound, activated receptors instigate intracellular signalling, which can then be manipulated to diagnose the disease.

User Reviews

UNIQe62fee2aaf975068-partinfo-00000000-QINU UNIQe62fee2aaf975068-partinfo-00000001-QINU

@@ Line 1: / Line 1: @@
 __NOTOC__
 This experience page is provided so that any user may enter their experience using this part.<BR>Please enter
@@ Line 5: / Line 4: @@
 ===Applications of BBa_K1391008===
+Lyn is a Tyrosine-protein kinase responsible for phosphorylating the immunoreceptor tyrosine-based activation motif (ITAM) of a B-Cell Receptor (BCR) Complex upon antigen binding. When the BCR binds it's specific antigen the receptor dimerizes and recruits Lyn which phosphorylates the ITAMs of the CD79A and CD79B proteins in the BCR Complex. This allows the receptor to phosphorylate Syk and initiate a downstream signalling cascade.
+B-cell receptors (BCRs) are naturally occurring, transmembrane protein complexes that consist of a membrane-bound antibody (IgM) and some associated proteins (CD79A and CD79B). Given that the variable region of the antibody can be specific for any of a large number of antigens, we designed a B-cell receptor to bind beta-amyloid plaques (a biomolecular hallmark of Alzheimer's disease). Once bound, activated receptors instigate intracellular signalling, which can then be manipulated to diagnose the disease.
 ===User Reviews===