Difference between revisions of "Part:BBa K1333107"

Revision as of 12:08, 26 October 2014

umuc

The UmuC is involved in the SOS DNA repair process.

Usage and Biology

When DNA encounters severe damage which may leads to critical problem of the cell, the most prior task is to stabilize the DNA as soon as possible, even at the cost of generate mutation. SOS bypass is an emergency DNA repair method of cells. The functional enzyme of SOS is polymerase V. When the external signal ,like UV, activate the RecA coprotease activity, it can help the lexA gene to cleave itself, which will result in several genes to be induced. UmuD and UmuC are two of the induced genes. The product of UmuD gene will be cleaved by a proteinase and turn into UmuD’. The complex of UmuD’ and UmuC has DNA polymerase activity, which is referred as polymerase V.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 177
Illegal BamHI site found at 1184
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal AgeI site found at 75
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 265

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 __NOTOC__
 <partinfo>BBa_K1333107 short</partinfo>
-umuc coding sequence
+The UmuC is involved in the SOS DNA repair process.
-<!-- Add more about the biology of this part here
 ===Usage and Biology===
+When DNA encounters severe damage which may leads to critical problem of the cell, the most prior task is to stabilize the DNA as soon as possible, even at the cost of generate mutation. SOS bypass is an emergency DNA repair method of cells. The functional enzyme of SOS is polymerase V. When the external signal ,like UV, activate the RecA coprotease activity, it can help the lexA gene to cleave itself, which will result in several genes to be induced. UmuD and UmuC are two of the induced genes. The product of UmuD gene will be cleaved by a proteinase and turn into UmuD’. The complex of UmuD’ and UmuC has DNA polymerase activity, which is referred as polymerase V.
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