Difference between revisions of "Part:BBa K1333106"

 
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<partinfo>BBa_K1333106 short</partinfo>
 
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umud'
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The UmuD' is involved in the SOS DNA repair process.
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===Usage and Biology===
 
===Usage and Biology===
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When DNA encounters severe damage which may leads to critical problem of the cell, the most prior task is to stabilize the DNA as soon as possible, even at the cost of generate mutation. SOS bypass is an emergency DNA repair method of cells. The functional enzyme of SOS is polymerase V. When the external signal ,like UV, activate the RecA coprotease activity, it can help the lexA gene to cleave itself, which will result in several genes to be induced. UmuD and UmuC are two of the induced genes. The product of UmuD gene will be cleaved by a proteinase and turn into UmuD’. The complex of UmuD’ and UmuC has DNA polymerase activity, which is referred as polymerase V.
  
 
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Revision as of 12:07, 26 October 2014

RBS umuD'

The UmuD' is involved in the SOS DNA repair process.


Usage and Biology

When DNA encounters severe damage which may leads to critical problem of the cell, the most prior task is to stabilize the DNA as soon as possible, even at the cost of generate mutation. SOS bypass is an emergency DNA repair method of cells. The functional enzyme of SOS is polymerase V. When the external signal ,like UV, activate the RecA coprotease activity, it can help the lexA gene to cleave itself, which will result in several genes to be induced. UmuD and UmuC are two of the induced genes. The product of UmuD gene will be cleaved by a proteinase and turn into UmuD’. The complex of UmuD’ and UmuC has DNA polymerase activity, which is referred as polymerase V.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]