Difference between revisions of "Part:BBa K1151000"

Revision as of 12:19, 26 September 2013

Nickel-responsive pleiotropic regulator (HpNikR)

The HpNikR protein is a pleiotropic regulator from Helicobacter pylori. In presence of nickel it can acts as an activator or a repressor depending of the specific promoter that contains its operator site. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel. This domain corresponds to the C-terminal regulatory domain which contains four nickel binding sites at the tetramer interface. Binding nickel, then a conformational change allows it to activate or repress trascription.

Usage and Biology

                                   Figure 1: HpNikR nickel-binding domain (tetramer).

Figure 2: Proteic sequence analysis with Uniprot.

Safety

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 8: / Line 8: @@
 ===Usage and Biology===
-[[File:Cattura.jpg]]                                           [[File:Cattura1.jpg]]
+                                                     [[File:Cattura.jpg]]
-'''Figure 1:''' HpNikR nickel-binding domain (tetramer).       '''Figure 2:''' Proteic sequence analysis with Uniprot.
+                                    '''Figure 1:''' HpNikR nickel-binding domain (tetramer).
+[[File:Cattura1.jpg]]
+'''Figure 2:''' Proteic sequence analysis with Uniprot.
 ===Safety===