Difference between revisions of "Part:BBa K847005"

Latest revision as of 00:21, 4 October 2012

''Deinococcus radiodurans'' Manganese Transporter, MntH

Deinococcus radiodurans is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, D. radiodurans can withstand up to 12,000 Gy. Current literature supports this finding with D. radiodurans’ unique genetic makeup which allows it to better handle radiation exposure. Manganese is a cofactor for many of the radiation stress mechanisms in the cell, and so manganese transporters bring manganese into the cell during radiation stress. These transporters are particularly well-known in D. radiodurans, and expressing these proteins in E. coli has shown promise (Haiyan and Baoming 2010).

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal NgoMIV site found at 135
Illegal NgoMIV site found at 927
Illegal NgoMIV site found at 1000
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K847005 short</partinfo>
-tba
+''Deinococcus radiodurans'' is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, ''D. radiodurans'' can withstand up to 12,000 Gy. Current literature supports this finding with ''D. radiodurans’'' unique genetic makeup which allows it to better handle radiation exposure. Manganese is a cofactor for many of the radiation stress mechanisms in the cell, and so manganese transporters bring manganese into the cell during radiation stress. These transporters are particularly well-known in ''D. radiodurans'', and expressing these proteins in ''E. coli'' has shown promise (Haiyan and Baoming 2010).
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-===Usage and Biology===
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