Difference between revisions of "Part:BBa K875009"

Revision as of 14:54, 24 September 2012

LL 37 - Cathelicidin

The LL 37 cathelicidin is a human antimicrobial peptide. The antimicrobial peptides (AMPs) are present in all species investigated. They form an important part of innate immunity, protecting the organism from infection by directly killing invading bacteria. It disrupts the bacteria membrane from outside and it is armless from inside. (Ulrich et al., 2006)

The eukaryotic toxin LL 37 was obtained by synthesis with the canonical prefix and suffix RFC10 compatible and it was optimized for E. coli expression.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 1: / Line 1: @@
 __NOTOC__
 <partinfo>BBa_K875009 short</partinfo>
-A new LL 37 bacteria toxin optimized for E. coli expression. The toxin disrupt the membrane from outside and is armless from inside.
+The LL 37 cathelicidin is a human antimicrobial peptide.
+The antimicrobial peptides (AMPs) are present in all species investigated. They form an important part of innate immunity, protecting the organism from infection by directly killing invading bacteria. It disrupts the bacteria membrane from outside and it is armless from inside. (Ulrich et al., 2006)
+The eukaryotic toxin LL 37 was obtained by synthesis with the canonical prefix and suffix RFC10 compatible and it was optimized for E. coli expression.