Difference between revisions of "Part:BBa K364201:Experience"
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how you used this part and how it worked out. | how you used this part and how it worked out. | ||
| − | === | + | ===Ligand=== |
| + | It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. | ||
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| + | PXR is alo activated by a large number of endogenous and exogenous chemicals including steroids, antibiotics, antimycotics, bile acids, hyperforin, a constituent of the herbal antidepressant St. John's Wort, and many other herbal compounds. | ||
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| + | ===Physiological functions of PXR=== | ||
| + | The primary function of PXR is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body. | ||
| + | |||
| + | One of the primary targets of PXR activation is the induction of CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs. In addition, PXR up regulates the expression of phase II conjugating enzymes such as glutathione S-transferase and phase III transport uptake and efflux proteins such as OATP2 and MDR1. | ||
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| + | ===Possible applications of PXR DBD=== | ||
This part can be used for assembling various nuclear receptor composites by fusing with different LBDs for subsequent research applications. | This part can be used for assembling various nuclear receptor composites by fusing with different LBDs for subsequent research applications. | ||
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| + | ===Applications of BBa_K364201=== | ||
Revision as of 16:40, 27 October 2010
This experience page is provided so that any user may enter their experience using this part.
Please enter
how you used this part and how it worked out.
Ligand
It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
PXR is alo activated by a large number of endogenous and exogenous chemicals including steroids, antibiotics, antimycotics, bile acids, hyperforin, a constituent of the herbal antidepressant St. John's Wort, and many other herbal compounds.
Physiological functions of PXR
The primary function of PXR is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body.
One of the primary targets of PXR activation is the induction of CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs. In addition, PXR up regulates the expression of phase II conjugating enzymes such as glutathione S-transferase and phase III transport uptake and efflux proteins such as OATP2 and MDR1.
Possible applications of PXR DBD
This part can be used for assembling various nuclear receptor composites by fusing with different LBDs for subsequent research applications.