Difference between revisions of "Part:BBa K364303:Experience"
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===Ligand=== | ===Ligand=== | ||
| − | The ligands of DAF-12 various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime. | + | The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime. |
===Physiological effects of DAF-12=== | ===Physiological effects of DAF-12=== | ||
Latest revision as of 01:45, 26 October 2010
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Ligand
The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime.
Physiological effects of DAF-12
daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan.
Possible applications od DAF-12 LBD
DAF-12 LBD can be fused with various DBDs to activate the expression of chosen genes by addition of dafachronic acids (ligand).
Applications of BBa_K364303
User Reviews
UNIQ76c9b201e4a50fe7-partinfo-00000000-QINU UNIQ76c9b201e4a50fe7-partinfo-00000001-QINU