Difference between revisions of "Part:BBa K364308"
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View the PXR LBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1SKX&bionumber=1]. | View the PXR LBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1SKX&bionumber=1]. | ||
− | [[Image:PXR-LBD with Rifampicin.jpg|800px|thumb|center| Structure of human Pregnan X receptor in complex with the macrolide antibiotic Rifampicin.]] | + | [[Image:PXR-LBD with Rifampicin.jpg|800px|thumb|center| Structure of human Pregnan X receptor ligand binding domain in complex with the macrolide antibiotic Rifampicin.]] |
Description of the PXR LBD crystal structure with reference here: [http://mend.endojournals.org/cgi/content/full/19/5/1125]. | Description of the PXR LBD crystal structure with reference here: [http://mend.endojournals.org/cgi/content/full/19/5/1125]. |
Latest revision as of 21:50, 25 October 2010
Human PXR LBD
PXR is a xenobiotic-activated member of the nuclear receptor superfamily of transcription factors. PXR is involved in transcriptional induction of hepatic xenobiotic-catabolizing cytochrome 3A enzymes, playing a fundamental role in protecting body tissues from toxic bile acids. PXR is almost exlcusively expressed in the gastrointestinal system (stomach, duodenum, jejunum, ileum, colon and gall bladder) and liver, with lower levels in the kidney and ovary. PXR dysfunction is associated with immune disorders (sclerosing cholangitis, inflammatory bowel disease) and biliary primary cirrhosis.
More on PXR here: [http://en.wikipedia.org/wiki/Pregnane_X_receptor].
PXR Uniprot: [http://www.uniprot.org/uniprot/O75469].
View the PXR LBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1SKX&bionumber=1].
Description of the PXR LBD crystal structure with reference here: [http://mend.endojournals.org/cgi/content/full/19/5/1125].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 134
Illegal BglII site found at 245
Illegal BamHI site found at 668 - 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]