Difference between revisions of "Part:BBa K364308"

Revision as of 18:31, 25 October 2010

Human PXR LBD

PXR is a xenobiotic-activated member of the nuclear receptor superfamily of transcription factors. PXR is involved in transcriptional induction of hepatic xenobiotic-catabolizing cytochrome 3A enzymes, playing a fundamental role in protecting body tissues from toxic bile acids. PXR is almost exlcusively expressed in the gastrointestinal system (stomach, duodenum, jejunum, ileum, colon and gall bladder) and liver, with lower levels in the kidney and ovary. PXR dysfunction is associated with immune disorders (sclerosing cholangitis, inflammatory bowel disease) and biliary primary cirrhosis.

Picture of gel electrophoresis: PXR LBD in pSB1C3 resulting an insert of 807 bp.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BglII site found at 134
Illegal BglII site found at 245
Illegal BamHI site found at 668
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

Revision as of 18:29, 25 October 2010 (view source) Mrtwister (Talk \| contribs) ← Older edit		Revision as of 18:31, 25 October 2010 (view source) Mrtwister (Talk \| contribs) Newer edit →
Line 5:		Line 5:


−	[[Image:PXR-LBD with Rifampicin.jpg\|800px\|thumb\|center\|]]	+	[[Image:PXR-LBD with Rifampicin.jpg\|800px\|thumb\|center\|Picture of gel electrophoresis: PXR LBD in pSB1C3 resulting an insert of 807 bp.]]

	[[Image:PXRLBD.jpg\|800px\|thumb\|center\|]]		[[Image:PXRLBD.jpg\|800px\|thumb\|center\|]]