Difference between revisions of "Part:BBa K364314:Experience"
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===Physiological functions of NHR8=== | ===Physiological functions of NHR8=== | ||
| − | + | NHR-8 is required for gut function and may respond to the food signal. | |
The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. | The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors. | ||
Revision as of 18:17, 25 October 2010
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Physiological functions of NHR8
NHR-8 is required for gut function and may respond to the food signal.
The nhr-8 gene mutants have abnormally low resistance to the toxins colchicine and chloroquine.This resembles the regulation of protective metabolic enzymes by xenobiotic-sensing nuclear receptors.
NHR-8 may thus mediate a subset of the resistance traits promoted by PGP-3.
Possible applications of NHR8 LBD
This LBD can be fused with different DBDs forming a composite hormone receptor for ligand regulated expression of specific genes and can also be a sensor for various lipid natured molecules.
Applications of BBa_K364314
User Reviews
UNIQ5ce3730198b4a1b5-partinfo-00000000-QINU UNIQ5ce3730198b4a1b5-partinfo-00000001-QINU