Difference between revisions of "Part:BBa K364201"

Revision as of 16:59, 25 October 2010

Human RXR DBD

RXRα is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXRα plays roles in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily. RXR-α is expressed in mulitple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the liver, preputial gland, skeletal muscle and skin. RXR-α variants have been associated with psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficit hyperactivity disorder (ADHD)) and immune (psoriasis) disorders.

More on RXRalpha here: [http://en.wikipedia.org/wiki/RXRA].

RXRalpha Uniprot: [http://www.uniprot.org/uniprot/P19793].

View the RXRa DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1RXR].

Picture of human RXR DNA binding domain

Description of the RXRa DBD crystal structure with references here:

High-resolution solution structure of the retinoid X receptor DNA-binding domain. Holmbeck SM, Foster MP, Casimiro DR, Sem DS, Dyson HJ, Wright PE. J Mol Biol. 1998 Aug 14;281(2):271-84.

Picture of gel electrophoresis: hRXRα DBD in pSB1C3 resulting an insert of 198 bp. Circular pSB1C3-hRXRα DBD can be seen as control on the gel.

Sequence and Features