Difference between revisions of "Part:BBa K364310:Experience"

Revision as of 23:13, 24 October 2010

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Physiological effects of EcR

Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).

Potential applications of EcR LBD

EcR LBD can be fused with different DBDs in order to activate downstream gene expression depending on the binding site of the DBD.

Applications of BBa_K364310

User Reviews

UNIQbe7e32603309c7e5-partinfo-00000000-QINU UNIQbe7e32603309c7e5-partinfo-00000001-QINU

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 ===Physiological effects of EcR===
-Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells.[1] This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).
+Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).
 ===Potential applications of EcR LBD===