Difference between revisions of "Part:BBa I10020"

 
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This is the DNA enconding a sythetic construct of the Clostridium botulinum neurotoxin type A. (typically used in Botox injections)
 
This is the DNA enconding a sythetic construct of the Clostridium botulinum neurotoxin type A. (typically used in Botox injections)
  
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WARNING: Botulinum toxin type A is an extremely potent neurotoxin and can lead to widespread muscle paralysis and neuron damage. 200-300 pg/kg is a lethal dose for a human being. When using this part, gain permissin from the federal patent office and practice great caution with promoters and RBS sequences that may be put in a device with it (they should be chosen to limit expression of the protein to safe amounts with respect to the system the part is being inserted into).
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Further information can be found on PubMed via the reference: Shone, C.C., Quinn, C.P., Foster, K.A. (1997) Recombinant toxin fragments. Patent, PCT (W0/98/07864)-A 22-AUG-1997.
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===Usage and Biology===
 
===Usage and Biology===
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-- Please enter your experience with this part here --
 
  
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<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
<partinfo>BBa_I10020 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_I10020 SequenceAndFeatures</partinfo>
  
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<!-- Uncomment this to enable Functional Parameter display
 
===Functional Parameters===
 
===Functional Parameters===
 
<partinfo>BBa_I10020 parameters</partinfo>
 
<partinfo>BBa_I10020 parameters</partinfo>
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Revision as of 00:46, 5 June 2006


-- No description --

This is the DNA enconding a sythetic construct of the Clostridium botulinum neurotoxin type A. (typically used in Botox injections)

WARNING: Botulinum toxin type A is an extremely potent neurotoxin and can lead to widespread muscle paralysis and neuron damage. 200-300 pg/kg is a lethal dose for a human being. When using this part, gain permissin from the federal patent office and practice great caution with promoters and RBS sequences that may be put in a device with it (they should be chosen to limit expression of the protein to safe amounts with respect to the system the part is being inserted into). Further information can be found on PubMed via the reference: Shone, C.C., Quinn, C.P., Foster, K.A. (1997) Recombinant toxin fragments. Patent, PCT (W0/98/07864)-A 22-AUG-1997.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]