Difference between revisions of "Part:BBa K5499007"

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===Usage and Biology===
 
===Usage and Biology===
LAMP2A is a lysosome-associated membrane protein that is involved in the loading of soluble proteins containing specific amino acid sequences (such as the KFERQ motif) into nascent exosomes located at the endosomal limiting membrane. This process is known as exosomal LAMP2A cargo loading (e-LLoC) and is related to intercellular and interorgan communication.
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The LAMP2A mature peptide is utilized in various biotechnological and therapeutic applications, particularly in the field of gene therapy and lysosomal enzyme replacement therapies. Its ability to mediate the delivery of proteins to lysosomes makes it valuable for treating lysosomal storage disorders and enhancing the clearance of aggregated proteins in neurodegenerative diseases.
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The LAMP2A mature peptide is an essential component of the lysosomal membrane and plays a pivotal role in chaperone-mediated autophagy (CMA). By facilitating the selective uptake of cytosolic proteins into the lysosome, it helps maintain cellular homeostasis. The LAMP2A-mediated pathway is critical for the degradation of damaged or misfolded proteins, thereby preventing cellular toxicity. Understanding the biology of LAMP2A is important for developing strategies to manipulate lysosomal function in various diseases.
  
 
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===Profile===
 
===Profile===
Name: Lysosome-associated membrane protein 2, isoform A (LAMP2A)
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Name: LAMP2A Mature Peptide
  
 
Base Pairs:1146 bp
 
Base Pairs:1146 bp
  
Origin: Homo sapiens, synthetic
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Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
  
Properties: a lysosome-associated membrane protein that serves as a receptor and channel for transporting cytosolic proteins
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Properties: The LAMP2A mature peptide plays a crucial role in lysosomal function, particularly in chaperone-mediated autophagy (CMA). It facilitates the recognition and translocation of specific cytosolic proteins into the lysosome for degradation. This peptide is characterized by its ability to interact with various proteins and is integral to maintaining cellular homeostasis and regulating lysosomal pathways.

Revision as of 19:12, 1 October 2024


LAMP2A mature peptide

Lysosome-associated membrane protein 2, isoform A (LAMP2A), serves as a receptor and channel for transporting cytosolic proteins.

Usage and Biology

The LAMP2A mature peptide is utilized in various biotechnological and therapeutic applications, particularly in the field of gene therapy and lysosomal enzyme replacement therapies. Its ability to mediate the delivery of proteins to lysosomes makes it valuable for treating lysosomal storage disorders and enhancing the clearance of aggregated proteins in neurodegenerative diseases.

The LAMP2A mature peptide is an essential component of the lysosomal membrane and plays a pivotal role in chaperone-mediated autophagy (CMA). By facilitating the selective uptake of cytosolic proteins into the lysosome, it helps maintain cellular homeostasis. The LAMP2A-mediated pathway is critical for the degradation of damaged or misfolded proteins, thereby preventing cellular toxicity. Understanding the biology of LAMP2A is important for developing strategies to manipulate lysosomal function in various diseases.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Profile

Name: LAMP2A Mature Peptide

Base Pairs:1146 bp

Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.

Properties: The LAMP2A mature peptide plays a crucial role in lysosomal function, particularly in chaperone-mediated autophagy (CMA). It facilitates the recognition and translocation of specific cytosolic proteins into the lysosome for degradation. This peptide is characterized by its ability to interact with various proteins and is integral to maintaining cellular homeostasis and regulating lysosomal pathways.