Difference between revisions of "Part:BBa K5382151"

Revision as of 05:41, 1 October 2024

4z domain-protein domain

The z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG). In studies, the z domain is used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues. The 4z domain, a tetramer of the z domain, has also been shown to be able to construct EVs displaying antibodies_[1], with similar binding activity as the z domain.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 487

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 <partinfo>BBa_K5382151 short</partinfo>
-z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG). In studies, z domains are used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues. The 4z domain, a tetramer of the z domain, has also been shown in the literature to be able to construct extracellular vesicles (EVs) displaying antibodies, with similar binding activity as the z domain
+The z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG). In studies, the z domain is used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues. The 4z domain, a tetramer of the z domain, has also been shown to be able to construct EVs displaying antibodies<sub>[1]</sub>, with similar binding activity as the z domain.
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