Difference between revisions of "Part:BBa K5477020"
Kateesc1700 (Talk | contribs) |
|||
| Line 4: | Line 4: | ||
CYP3A4 (Cytochrome P450 3A4) is one of the most important enzymes in the cytochrome P450 family, which is responsible for the metabolism of a wide variety of xenobiotics, including drugs, environmental chemicals, and endogenous compounds. CYP3A4 is predominantly found in the liver and the intestines, where it plays a central role in phase I metabolism, which involves the oxidation of substrates to make them more polar and easier to excrete from the body. This enzyme metabolizes approximately 50% of all clinically used drugs, including antihistamines, antibiotics, statins, and antiretrovirals, making it essential for drug detoxification and clearance. CYP3A4 functions by introducing an oxygen atom into its substrates, often creating a reactive intermediate that is further processed by phase II enzymes such as UDP-glucuronosyltransferases (UGTs), which conjugate these intermediates with molecules like glucuronic acid to enhance their solubility. CYP3A4 is also involved in the metabolism of environmental toxins, including polycyclic aromatic hydrocarbons (PAHs) and certain pesticides, contributing to the body's defense against harmful chemicals. | CYP3A4 (Cytochrome P450 3A4) is one of the most important enzymes in the cytochrome P450 family, which is responsible for the metabolism of a wide variety of xenobiotics, including drugs, environmental chemicals, and endogenous compounds. CYP3A4 is predominantly found in the liver and the intestines, where it plays a central role in phase I metabolism, which involves the oxidation of substrates to make them more polar and easier to excrete from the body. This enzyme metabolizes approximately 50% of all clinically used drugs, including antihistamines, antibiotics, statins, and antiretrovirals, making it essential for drug detoxification and clearance. CYP3A4 functions by introducing an oxygen atom into its substrates, often creating a reactive intermediate that is further processed by phase II enzymes such as UDP-glucuronosyltransferases (UGTs), which conjugate these intermediates with molecules like glucuronic acid to enhance their solubility. CYP3A4 is also involved in the metabolism of environmental toxins, including polycyclic aromatic hydrocarbons (PAHs) and certain pesticides, contributing to the body's defense against harmful chemicals. | ||
| + | |||
| + | In the context of our system, CYP3A4 is integrated into a detoxification module where it initiates the oxidative breakdown of toxic compounds, such as pharmaceuticals and environmental pollutants, allowing these substances to be further processed and excreted. The inclusion of CYP3A4 in our detox module provides a broad-spectrum solution for metabolizing diverse toxins and drugs. This part was combined with POR. The following composites and devices, where this part was used, is listed below: | ||
| Line 18: | Line 20: | ||
<partinfo>BBa_K5477020 parameters</partinfo> | <partinfo>BBa_K5477020 parameters</partinfo> | ||
<!-- --> | <!-- --> | ||
| + | |||
| + | ===References=== | ||
| + | 1. Klyushova LS, Perepechaeva ML, Grishanova AY. The Role of CYP3A in Health and Disease. Biomedicines. 2022 Oct 24;10(11):2686. doi: 10.3390/biomedicines10112686. PMID: 36359206; PMCID: PMC9687714. | ||
| + | |||
| + | 2. Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391-396. | ||
Revision as of 17:35, 26 September 2024
CYP3A4 - Cytochrome P450 3A4 codon-optimized for Saccharomyces cerevisiae
CYP3A4 (Cytochrome P450 3A4) is one of the most important enzymes in the cytochrome P450 family, which is responsible for the metabolism of a wide variety of xenobiotics, including drugs, environmental chemicals, and endogenous compounds. CYP3A4 is predominantly found in the liver and the intestines, where it plays a central role in phase I metabolism, which involves the oxidation of substrates to make them more polar and easier to excrete from the body. This enzyme metabolizes approximately 50% of all clinically used drugs, including antihistamines, antibiotics, statins, and antiretrovirals, making it essential for drug detoxification and clearance. CYP3A4 functions by introducing an oxygen atom into its substrates, often creating a reactive intermediate that is further processed by phase II enzymes such as UDP-glucuronosyltransferases (UGTs), which conjugate these intermediates with molecules like glucuronic acid to enhance their solubility. CYP3A4 is also involved in the metabolism of environmental toxins, including polycyclic aromatic hydrocarbons (PAHs) and certain pesticides, contributing to the body's defense against harmful chemicals.
In the context of our system, CYP3A4 is integrated into a detoxification module where it initiates the oxidative breakdown of toxic compounds, such as pharmaceuticals and environmental pollutants, allowing these substances to be further processed and excreted. The inclusion of CYP3A4 in our detox module provides a broad-spectrum solution for metabolizing diverse toxins and drugs. This part was combined with POR. The following composites and devices, where this part was used, is listed below:
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal XbaI site found at 1483
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal XbaI site found at 1483
- 25INCOMPATIBLE WITH RFC[25]Illegal XbaI site found at 1483
- 1000COMPATIBLE WITH RFC[1000]
References
1. Klyushova LS, Perepechaeva ML, Grishanova AY. The Role of CYP3A in Health and Disease. Biomedicines. 2022 Oct 24;10(11):2686. doi: 10.3390/biomedicines10112686. PMID: 36359206; PMCID: PMC9687714.
2. Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391-396.