Difference between revisions of "Part:BBa K5107001"
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<partinfo>BBa_K5107001 short</partinfo>
 
<partinfo>BBa_K5107001 short</partinfo>
  
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Estrogen Response Element (ERE) is the consensus sequence for the binding site of the estrogen receptor.
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Estrogen Response Element (ERE) is the consensus sequence for the binding site of the estrogen receptor[1].
  
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===Usage and Biology===
 
===Usage and Biology===
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These inverted repeats are responsible for the interaction of the DNA Binding Domain (DBD) of the receptor with the DNA. In the human cells, these nuclear receptors work mainly as transctription activators when the hormone is present in the cytoplasm. There, protein-hormone interactions trigger the translocation of the receptor to the nucleus where the transcription takes place. Because of the absence of the cofactors in the cell free system, these sites are used as operator sites, meaning that the nuclear receptor-hormone complex can bind to these and block the transcription of the upstream promoter.
 
  
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These inverted repeats are responsible for the interaction of the DNA Binding Domain (DBD) of the receptor with the DNA. In the human cells, these nuclear receptors work mainly as transctription activators when the hormone is present in the cytoplasm[2]. There, protein-hormone interactions trigger the translocation of the receptor to the nucleus where the transcription takes place. Because of the absence of the cofactors in the cell free system, these sites are used as operator sites, meaning that the nuclear receptor-hormone complex can bind to these and block the transcription of the upstream promoter.
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<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K5107001 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K5107001 SequenceAndFeatures</partinfo>
  
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===Functional Parameters===
 
===Functional Parameters===
 
<partinfo>BBa_K5107001 parameters</partinfo>
 
<partinfo>BBa_K5107001 parameters</partinfo>
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===Referencies===
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Revision as of 17:02, 22 September 2024


ERE minimal

Estrogen Response Element (ERE) is the consensus sequence for the binding site of the estrogen receptor[1].

Usage and Biology

These inverted repeats are responsible for the interaction of the DNA Binding Domain (DBD) of the receptor with the DNA. In the human cells, these nuclear receptors work mainly as transctription activators when the hormone is present in the cytoplasm[2]. There, protein-hormone interactions trigger the translocation of the receptor to the nucleus where the transcription takes place. Because of the absence of the cofactors in the cell free system, these sites are used as operator sites, meaning that the nuclear receptor-hormone complex can bind to these and block the transcription of the upstream promoter.


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]