Difference between revisions of "Part:BBa K5387000"

 
Line 1: Line 1:
 +
__NOTOC__
 +
<partinfo>BBa_K5387000 short</partinfo>
  
 +
===Description===
 +
ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010].
 +
 +
The gene codes for one of the enzymes used for [https://2024.igem.wiki/linkoping/ iGEM24_Linkoping] substitution therapy for Ichthyosis.
 +
 +
===Sequence===
 +
<partinfo>BBa_K5387000 SequenceAndFeatures</partinfo>
 +
 +
===References===
 +
https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010 UTFÖRLIGARE

Revision as of 08:43, 20 August 2024

ALOX12B

Description

ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [1]. 

The gene codes for one of the enzymes used for iGEM24_Linkoping substitution therapy for Ichthyosis.

Sequence


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 1789
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 722
    Illegal BamHI site found at 2070
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 1747
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 454

References

https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010 UTFÖRLIGARE