Difference between revisions of "Part:BBa K4645023"
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MntA is the antitoxin of the toxin protein HepT. Together they form a toxin-antitoxin system. The HepT/MntA system belongs to type VII TA, where the antitoxin neutralizes the toxicity of the toxin not through direct interaction, but by post-translational modification of the toxin's active site. MntA can bind to HepT and polyadenylate HepT, thereby neutralizing the toxicity of HepT and reducing its RNase activity [1].
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===Reference===
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<p>[1]Wang X, Yao J, Sun YC, Wood TK. Type VII Toxin/Antitoxin Classification System for Antitoxins that Enzymatically Neutralize Toxins. Trends Microbiol. 2021 May;29(5):388-393.</p>
  
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MntA(MNT-domain protein) is the antitoxin of the HepT toxin. HepT/MntA is one kind of Toxin/Antitoxin (TA) systems in which the enzyme antitoxin chemically modifies the toxin to neutralize it. MntA(MNT-domain protein) could polyadenylylate HepT and reduce HepT toxicity.
 
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===Usage and Biology===
 
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===Sequence and Features===
 
===Sequence and Features===
 
<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
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===Functional Parameters===
 
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<partinfo>BBa_K4645023 parameters</partinfo>
 
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Revision as of 13:41, 12 October 2023

MntA (MNT-domain protein)：An antitoxin MntA is the antitoxin of the toxin protein HepT. Together they form a toxin-antitoxin system. The HepT/MntA system belongs to type VII TA, where the antitoxin neutralizes the toxicity of the toxin not through direct interaction, but by post-translational modification of the toxin's active site. MntA can bind to HepT and polyadenylate HepT, thereby neutralizing the toxicity of HepT and reducing its RNase activity [1].

Reference

[1]Wang X, Yao J, Sun YC, Wood TK. Type VII Toxin/Antitoxin Classification System for Antitoxins that Enzymatically Neutralize Toxins. Trends Microbiol. 2021 May;29(5):388-393.

Sequence and Features

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]