Difference between revisions of "Part:BBa K4613010"

Revision as of 01:53, 9 October 2023

Elastin-like Polypeptide(GVGVP)(15)

Elastin-like polypeptides(ELPs) are protein polymers derived from human tropoelastin. One of their key features is that they exhibit phase separation that is often reversible whereby samples remain soluble below a transition temperature(Tt) but form coacervates above Tt. They have many possible applications for sensing, activation, and nano assembly. Furthermore, they are non-immunogenic, substrates for proteolytic biodegradation, and can be decorated with functional peptides, proteins, and small molecules. The general structure of polymeric ELPs is (GVGVP)(15）, where the monomeric unit is Gly-Val-Gly-Val-Pro. The NAU-CHINA 2023 team used this part in versatile model systems for biomaterials development. The polymerization between ELPs containing SpyTags and one containing SpyCatchers can proceed efficiently in a wine production environment.

Reference

1. Duan T, Li H.In Situ Phase Transition of Elastin-Like Polypeptide Chains Regulates Thermoresponsive Properties of Elastomeric Protein-Based Hydrogels[J].Biomacromolecules,2020, 21 (6): 2258-2267.
2. Dai Z, Yang X, Wu F, et al.Living fabrication of functional semi-interpenetrating polymeric materials[J].Nat Commun,2021, 12 (1): 3422.

Sequence and Features