Difference between revisions of "Part:BBa K200013"
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<partinfo>BBa_K200013 short</partinfo> | <partinfo>BBa_K200013 short</partinfo> | ||
| − | =Background= | + | ==Background== |
Opiorphin is a pentapeptide (five amino acids long) that was isolated from human saliva in 1996. The amino acid sequence for opiorphin is Glutamine-Arginine-Phenylalanine-Serine-Arginine. | Opiorphin is a pentapeptide (five amino acids long) that was isolated from human saliva in 1996. The amino acid sequence for opiorphin is Glutamine-Arginine-Phenylalanine-Serine-Arginine. | ||
Preliminary rat studies indicate that opiorphin has a pain killing effect six times stronger than that of morphine. With regards to its mechanism of action, opiorphin prevents the breakdown of enkephalins which are natural pain-killing opioids. | Preliminary rat studies indicate that opiorphin has a pain killing effect six times stronger than that of morphine. With regards to its mechanism of action, opiorphin prevents the breakdown of enkephalins which are natural pain-killing opioids. | ||
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| + | ==EK Cleavage== | ||
| + | |||
| + | See 'Design Notes' for our rationale behind incorporating an EK cleavage sequence on the N terminus of the opiorphin pentapeptide. | ||
Revision as of 14:47, 18 October 2009
Opiorphin + EK cleavage site
Background
Opiorphin is a pentapeptide (five amino acids long) that was isolated from human saliva in 1996. The amino acid sequence for opiorphin is Glutamine-Arginine-Phenylalanine-Serine-Arginine.
Preliminary rat studies indicate that opiorphin has a pain killing effect six times stronger than that of morphine. With regards to its mechanism of action, opiorphin prevents the breakdown of enkephalins which are natural pain-killing opioids.
EK Cleavage
See 'Design Notes' for our rationale behind incorporating an EK cleavage sequence on the N terminus of the opiorphin pentapeptide.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]