Difference between revisions of "Part:BBa K4839008"

Revision as of 17:28, 3 October 2023

IRF4 Binding protein

Our modeling work also contribute to our part collection. In order to directly target to the IRF4 protein (Figure 1.), we synthesis an IRF4 binding protein through modeling. The detailed process of our modeling work can be found on the model page.

Figure1. The function of anti-IRF4 BioPROTAC

With the help of computer modeling including molecular dynamics, we succeedly synthesis the Anti-IRF4 protein, which is called IRF4 binding protein here. The IRF4 binding protein can specifically binds to the IRF4 protein, and thus the BioPROTAC will trigger the degradation of the IRF4 and furher lead to the changing of the phenotype of the macrophage.

[1] Lim S , Khoo R , Peh K M ,et al.bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)[J].Proceedings of the National Academy of Sciences, 2020(11).DOI:10.1073/PNAS.1920251117.

[2] Békés, M., Langley, D.R. & Crews, C.M. PROTAC targeted protein degraders: the past is prologue. Nat Rev Drug Discov 21, 181–200 (2022). https://doi.org/10.1038/s41573-021-00371-6

Sequence and Features