Difference between revisions of "Part:BBa K4839008"

 
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<partinfo>BBa_K4839008 short</partinfo>
 
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Our modeling work also contribute to our part collection. In order to directly target to the IRF4 protein (Figure 3.), we synthesis an IRF4 binding protein through modeling. The detailed process of our modeling work can be found on the model page.
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Our modeling work also contribute to our part collection. In order to directly target to the IRF4 protein (Figure 1.), we synthesis an IRF4 binding protein through modeling. The detailed process of our modeling work can be found on the model page.
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<html><img src="https://static.igem.wiki/teams/4839/wiki/parts-files/7-1.png" width="650"</html>
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<p align="center">Figure1. The function of anti-IRF4 BioPROTAC</p>
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With the help of computer modeling including molecular dynamics, we succeedly synthesis the Anti-IRF4 protein, which is called IRF4 binding protein here. The IRF4 binding protein can specifically binds to the IRF4 protein, and thus the BioPROTAC will trigger the degradation of the IRF4 and furher lead to the changing of the phenotype of the macrophage.
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Revision as of 14:38, 3 October 2023


IRF4 Binding protein

Our modeling work also contribute to our part collection. In order to directly target to the IRF4 protein (Figure 1.), we synthesis an IRF4 binding protein through modeling. The detailed process of our modeling work can be found on the model page.


Figure1. The function of anti-IRF4 BioPROTAC

With the help of computer modeling including molecular dynamics, we succeedly synthesis the Anti-IRF4 protein, which is called IRF4 binding protein here. The IRF4 binding protein can specifically binds to the IRF4 protein, and thus the BioPROTAC will trigger the degradation of the IRF4 and furher lead to the changing of the phenotype of the macrophage.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 271
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 271
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 271
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 271
    Illegal AgeI site found at 548
  • 1000
    COMPATIBLE WITH RFC[1000]