Difference between revisions of "Part:BBa K4656002"
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   <li style="display: inline-block;"> [[File:tdc-tph.jpeg|thumb|none|400px|<b></b> Pathway of NFAT and its downstream structure.]] </li>
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   Pathway of NFAT and its downstream  
 
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Revision as of 12:55, 11 September 2023


TPH

Tph also plays an important role in the synthesis of serotonin, in which the rate-limiting step is catalyzed by TPH，converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP). 



     Pathway of NFAT and its downstream

Usage and Biology

As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 898
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 673
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 240