Difference between revisions of "Part:BBa K4656002"
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<partinfo>BBa_K4656002 short</partinfo>
 
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Tph plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH， converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).  
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Tph also plays an important role in the synthesis of serotonin, in which the rate-limiting step is catalyzed by TPH，converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).  
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https://static.igem.wiki/teams/4656/wiki/tdc-tph.jpg
  
 
===Usage and Biology===
 
===Usage and Biology===

Revision as of 16:59, 10 September 2023


TPH

Tph also plays an important role in the synthesis of serotonin, in which the rate-limiting step is catalyzed by TPH，converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP). tdc-tph.jpg

Usage and Biology

As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 898
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 673
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 240