Difference between revisions of "Part:BBa K4656002"
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As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, constructing plasmids introducing Tph1 gene and promoting TPH expression is conducive to the treatment of chronic constipation. | As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, constructing plasmids introducing Tph1 gene and promoting TPH expression is conducive to the treatment of chronic constipation. | ||
| − | + | ===Sequence and Features=== | |
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<partinfo>BBa_K4656002 SequenceAndFeatures</partinfo> | <partinfo>BBa_K4656002 SequenceAndFeatures</partinfo> | ||
Revision as of 15:25, 7 September 2023
TPH
Tph1 is the gene encoding tryptophan hydroxylase (TPH), which plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH. The Tph1 gene expresses the TPH1 protein, which converts tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
Usage and Biology
As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, constructing plasmids introducing Tph1 gene and promoting TPH expression is conducive to the treatment of chronic constipation.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 898
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 673
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 240