Difference between revisions of "Part:BBa K4165105"
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===Usage and Biology===
 
===Usage and Biology===
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Synthetic peptide acquired by Phage display, Binds specifically to PDZ domain of HTRA1 and HTRA3 Proteins with  ΔG of –7.1 kJ.mol<sup>-1</sup> and IC<sub>50<sub> of 23 ± 3
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Synthetic peptide acquired by Phage display, Binds specifically to PDZ domain of HTRA1 and HTRA3 Proteins with  ΔG of –7.1 kJ.mol<sup>-1</sup> and IC<sub>50</sub> of 23 ± 3
  
 
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Revision as of 20:13, 10 October 2022


HTRA Binding Peptide 11

part encodes for a synthetic peptide that binds to the PDZ domain of HTRA1 protein

Usage and Biology

Synthetic peptide acquired by Phage display, Binds specifically to PDZ domain of HTRA1 and HTRA3 Proteins with ΔG of –7.1 kJ.mol-1 and IC50 of 23 ± 3

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Functional Parameters

Got score of 5 out of 6 in our Quality assessment code after modeling by AlphaFold2.0

cbeta_deviations = 0, clashscore = 25, molprobity = 3.86, ramachandran_favored = 66.67, ramachandran_outliers = 16.67, Qmean_4 = -6.45183, Qmean6 = -5.513969

Modeling


                 Figure 1.: 3D Model of H1K peptide Modelled by AlphaFold2.0 displayed in Pyomol