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− | 1. Stewart, M. D., Ritterhoff, T., Klevit, R. E., & Brzovic, P. S. (2016). E2 enzymes: more than just middle men. Cell research, 26(4), 423-440. | + | 1. Stewart, M. D., Ritterhoff, T., Klevit, R. E., & Brzovic, P. S. (2016). E2 enzymes: more than just middle men. Cell research, 26(4), 423-440. |
Revision as of 14:48, 10 October 2022
UBE2W
Ubiquitin-conjugating E2 ligase that has a role in the ubiquitination cascade for protein degradation.
Usage and Biology
This E2 ubiquitin-conjugating enzyme UBE2W is the key participant in the trio of enzymes as it is responsible for the monoubiquitylation of TRIM21 E3 ligase to initiate its polyubiquitylation by the UBE2N/UBE2V2 heterodimer.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
References
1. Stewart, M. D., Ritterhoff, T., Klevit, R. E., & Brzovic, P. S. (2016). E2 enzymes: more than just middle men. Cell research, 26(4), 423-440.